BDBM50302422 6-chloro-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazole::CHEMBL568545

SMILES Fc1cccc(Cl)c1-c1nc2c([nH]1)c1ccc(Cl)cc1c1ccccc21

InChI Key InChIKey=VRYRXTPTQGLEIW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50302422   

TargetProstaglandin E synthase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50302422(6-chloro-2-(2-chloro-6-fluorophenyl)-1H-phenanthro...)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]PGH2 from human recombinant PGES1 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50302422(6-chloro-2-(2-chloro-6-fluorophenyl)-1H-phenanthro...)
Affinity DataIC50: 710nMAssay Description:Inhibition of mPGES1 in IL-1-beta-stimulated human A549 cells assessed as blockade of PGH2 to PGE2 conversion in presence of 50% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed