BDBM50302564 CHEMBL577904::N-(((cis)-4-(4-(dimethylamino)-5-methylpyrimidin-2-ylamino)cyclohexyl)methyl)-3,4-difluorobenzamide

SMILES CN(C)c1nc(N[C@@H]2CC[C@H](CNC(=O)c3ccc(F)c(F)c3)CC2)ncc1C

InChI Key InChIKey=NFQWOMAFZMZYOX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50302564   

TargetMelanin-concentrating hormone receptor 1(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302564(N-(((cis)-4-(4-(dimethylamino)-5-methylpyrimidin-2...)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302564(N-(((cis)-4-(4-(dimethylamino)-5-methylpyrimidin-2...)
Affinity DataIC50: 210nMAssay Description:Displacement of [3H]MK-912 from human adrenergic alpha2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302564(N-(((cis)-4-(4-(dimethylamino)-5-methylpyrimidin-2...)
Affinity DataIC50: 320nMAssay Description:Displacement of [3H]rauwolsine from human 5HT2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302564(N-(((cis)-4-(4-(dimethylamino)-5-methylpyrimidin-2...)
Affinity DataIC50: 920nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302564(N-(((cis)-4-(4-(dimethylamino)-5-methylpyrimidin-2...)
Affinity DataIC50: 3.60E+3nMAssay Description:Displacement of [3H]prazosin from human adrenergic alpha1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed