BDBM50303223 6-(2,6-dichlorophenyl)-2-(4-(2-hydroxyethyl)phenylamino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one::CHEMBL576218

SMILES Cn1c2nc(Nc3ccc(CCO)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O

InChI Key InChIKey=HTZNZEKPDCTESZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303223   

TargetTyrosine-protein kinase ABL1(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303223(6-(2,6-dichlorophenyl)-2-(4-(2-hydroxyethyl)phenyl...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human recombinant AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303223(6-(2,6-dichlorophenyl)-2-(4-(2-hydroxyethyl)phenyl...)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303223(6-(2,6-dichlorophenyl)-2-(4-(2-hydroxyethyl)phenyl...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant P38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303223(6-(2,6-dichlorophenyl)-2-(4-(2-hydroxyethyl)phenyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant C-KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed