BDBM50303227 6-(2,6-dichlorophenyl)-8-methyl-2-(4-(4-methylpiperazine-1-carbonyl)phenylamino)pyrido[2,3-d]pyrimidin-7(8H)-one::CHEMBL565366

SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1

InChI Key InChIKey=KNXQEJUJQOZAKP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303227   

TargetTyrosine-protein kinase ABL1(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303227(6-(2,6-dichlorophenyl)-8-methyl-2-(4-(4-methylpipe...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human recombinant AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303227(6-(2,6-dichlorophenyl)-8-methyl-2-(4-(4-methylpipe...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant P38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303227(6-(2,6-dichlorophenyl)-8-methyl-2-(4-(4-methylpipe...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303227(6-(2,6-dichlorophenyl)-8-methyl-2-(4-(4-methylpipe...)
Affinity DataIC50: 235nMAssay Description:Inhibition of human recombinant C-KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed