BDBM50304110 (Z)-5'-Amino-1H,1'H-[2,3']biindolylidene-3,2'-dione::5'-Amino-1H,1'H-[2,3']biindolylidene-3,2'-dione::CHEMBL594192

SMILES Nc1ccc2NC(=O)C(=C3Nc4ccccc4C3=O)c2c1

InChI Key InChIKey=UKVQMBJHWHGXOI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50304110   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50304110((Z)-5'-Amino-1H,1'H-[2,3']biindolylidene-3,2'-dion...)
Affinity DataIC50: 359nMAssay Description:Inhibition of FLT3 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
La Rochelle University

Curated by ChEMBL
LigandPNGBDBM50304110((Z)-5'-Amino-1H,1'H-[2,3']biindolylidene-3,2'-dion...)
Affinity DataIC50: 590nMAssay Description:Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 17B(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50304110((Z)-5'-Amino-1H,1'H-[2,3']biindolylidene-3,2'-dion...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details Article
PubMed
LigandPNGBDBM50304110((Z)-5'-Amino-1H,1'H-[2,3']biindolylidene-3,2'-dion...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed