BDBM50304216 CHEMBL593294::N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-7'-methoxy-6'-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4'-amine

SMILES COc1cc2ncnc(Nc3ccc(cc3O)-c3nc4ccccc4s3)c2cc1OCCCN1CCN(C)CC1

InChI Key InChIKey=DPYASQWYHILTBI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50304216   

TargetEpidermal growth factor receptor(Human)
4Sc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304216BDBM50304216(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-7'-...)
Affinity DataIC50: 230nMAssay Description:Inhibition of wild type EGF-R by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
4Sc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304216BDBM50304216(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-7'-...)
Affinity DataIC50: 800nMAssay Description:Inhibition of Aurora-A by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
4Sc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304216BDBM50304216(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-7'-...)
Affinity DataIC50: 800nMAssay Description:Inhibition of Aurora-B by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
4Sc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304216BDBM50304216(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-7'-...)
Affinity DataIC50: 880nMAssay Description:Inhibition of TIE2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50304216BDBM50304216(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-7'-...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of ERBB2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50304216BDBM50304216(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-7'-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRbeta by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed