BDBM50304491 CHEMBL611925::H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-Pro-Leu-Trp-NH-[3',5'-(CF3)2Bzl]

SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=ATLZVWRXMUZKNV-UHFFFAOYSA-N

Data  6 KI  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50304491   

TargetSubstance-P receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304491(H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-Pro-Leu-Trp-NH-[3',5'...)
Affinity DataKi:  0.520nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304491(H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-Pro-Leu-Trp-NH-[3',5'...)
Affinity DataKi:  0.520nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304491(H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-Pro-Leu-Trp-NH-[3',5'...)
Affinity DataKi:  7.80nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in HN9.10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304491(H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-Pro-Leu-Trp-NH-[3',5'...)
Affinity DataIC50: 8.30nMAssay Description:Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304491(H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-Pro-Leu-Trp-NH-[3',5'...)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304491(H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-Pro-Leu-Trp-NH-[3',5'...)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304491(H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-Pro-Leu-Trp-NH-[3',5'...)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptor expressed in HN9.10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304491(H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-Pro-Leu-Trp-NH-[3',5'...)
Affinity DataEC50:  98nMAssay Description:Agonist activity at human delta opioid receptor expressed in HN9.10 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304491(H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-Pro-Leu-Trp-NH-[3',5'...)
Affinity DataEC50:  170nMAssay Description:Agonist activity at rat mu opioid receptor expressed in HN9.10 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304491(H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-Pro-Leu-Trp-NH-[3',5'...)
Affinity DataEC50:  170nMAssay Description:Agonist activity at rat mu opioid receptor expressed in HN9.10 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304491(H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-Pro-Leu-Trp-NH-[3',5'...)
Affinity DataIC50: 280nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed