BDBM50304865 CHEMBL607429::N-(3-(1,2-dimethyl-3-oxo-5-(quinoxalin-6-yl)-2,3-dihydro-1H-pyrazol-4-yl)phenyl)methanesulfonamide

SMILES Cn1c(c(-c2cccc(NS(C)(=O)=O)c2)c(=O)n1C)-c1ccc2nccnc2c1

InChI Key InChIKey=YXZXTOAUUFWDRG-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50304865   

TargetTGF-beta receptor type-1(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50304865(N-(3-(1,2-dimethyl-3-oxo-5-(quinoxalin-6-yl)-2,3-d...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50304865(N-(3-(1,2-dimethyl-3-oxo-5-(quinoxalin-6-yl)-2,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed