BDBM50304944 CHEMBL595474::N-(2-hydroxy-2-phenylethyl)-6-(4-(2-methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxamide

SMILES Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1ccccc1

InChI Key InChIKey=QTBRDMNOZGAPAG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50304944   

TargetAcyl-CoA desaturase 1(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304944(N-(2-hydroxy-2-phenylethyl)-6-(4-(2-methylbenzoyl)...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Scd1 in mouse liver microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304944(N-(2-hydroxy-2-phenylethyl)-6-(4-(2-methylbenzoyl)...)
Affinity DataIC50: 7nMAssay Description:Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304944(N-(2-hydroxy-2-phenylethyl)-6-(4-(2-methylbenzoyl)...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Scd1 in human HEK293A cell microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304944(N-(2-hydroxy-2-phenylethyl)-6-(4-(2-methylbenzoyl)...)
Affinity DataIC50: 15nMAssay Description:Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304944(N-(2-hydroxy-2-phenylethyl)-6-(4-(2-methylbenzoyl)...)
Affinity DataIC50: 51nMAssay Description:Inhibition of human Scd1 expressed in HEK293A cells assessed as conversion of [14C]stearate to [14C]oleate pretreated for 30 mins measured after 4 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed