BDBM50304945 CHEMBL591562::N-(2-hydroxy-2-phenylethyl)-6-(4-(2-methoxybenzoyl)piperidin-1-yl)pyridazine-3-carboxamide

SMILES COc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1ccccc1

InChI Key InChIKey=PSOBORQSDNHBBG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50304945   

TargetAcyl-CoA desaturase 1(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304945(N-(2-hydroxy-2-phenylethyl)-6-(4-(2-methoxybenzoyl...)
Affinity DataIC50: 52nMAssay Description:Inhibition of Scd1 in mouse liver microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304945(N-(2-hydroxy-2-phenylethyl)-6-(4-(2-methoxybenzoyl...)
Affinity DataIC50: 311nMAssay Description:Inhibition of Scd1 in human HEK293A cell microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304945(N-(2-hydroxy-2-phenylethyl)-6-(4-(2-methoxybenzoyl...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of human Scd1 expressed in HEK293A cells assessed as conversion of [14C]stearate to [14C]oleate pretreated for 30 mins measured after 4 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed