BDBM50305154 (4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2(7),3,5,10,13,15-heptaen-9-yl}phenyl)methanol::CHEMBL592034

SMILES OCc1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23

InChI Key InChIKey=NIBBSZDCZSIRFX-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50305154   

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305154((4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,1...)
Affinity DataKi:  3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305154((4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,1...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of JAK2 in granulocyte macrophage colony stimulating factor-stimulated human TF1 cells assessed as phosphorylation of STAT5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed