BDBM50305457 CHEMBL591340::methyl 2-((R)-((R)-1-((S)-1-amino-3-cyclohexylpropan-2-ylcarbamoyl)piperidin-3-yl)(3-fluorophenyl)methoxy)ethylcarbamate

SMILES COC(=O)NCCO[C@H]([C@@H]1CCCN(C1)C(=O)N[C@H](CN)CC1CCCCC1)c1cccc(F)c1

InChI Key InChIKey=PZCYFIHOVJAVDW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50305457   

TargetRenin(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305457(methyl 2-((R)-((R)-1-((S)-1-amino-3-cyclohexylprop...)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetRenin(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305457(methyl 2-((R)-((R)-1-((S)-1-amino-3-cyclohexylprop...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human recombinant renin assessed as decrease in plasma renin activity by competitive radioimmunoassay in presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed