BDBM50305546 1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-methylurea::CHEMBL589858

SMILES CNC(=O)Nc1ccc(cc1)-c1nc(C2=CCOCC2)c2cnn(CC(F)(F)F)c2n1

InChI Key InChIKey=WARHZMCNVITGFR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50305546   

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305546(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50305546(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifl...)
Affinity DataIC50: 200nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed