BDBM50306503 4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-N-phenylbutanamide::CHEMBL602703

SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccccc4)C(F)(F)F)cc3F)c2s1

InChI Key InChIKey=ZXXJTQRLPRCGMZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50306503   

TargetVascular endothelial growth factor receptor 2(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50306503(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50306503(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50306503(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50306503(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50: 120nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50306503(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50: 600nMAssay Description:Inhibition of TPR-fused Met autophosphorylation expressed in HEK293T cells after 150 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50306503(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50306503(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of c-MET in human DU145 cells by scattering assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50306503(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of c-MET in human A549 cells by wound healing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed