BDBM50307880 CHEMBL598626::N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)benzamide

SMILES CC(C)(C)c1cc(NC(=O)c2cccc(Oc3cccc4[nH]c(=O)[nH]c34)c2)n(n1)-c1ccccc1

InChI Key InChIKey=GLDPXWNDIUPOHH-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50307880   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 126nMAssay Description:Inhibition of cRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 202nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 883nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of wild type BRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of p38alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 4.16E+3nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 4.25E+3nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 7.49E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 9.71E+3nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38-gamma MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed