BDBM50309549 3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione::CHEMBL606168::US9364459, O

SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccc(F)cc12

InChI Key InChIKey=HRUYZDJOLIPWLW-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50309549   

TargetVascular endothelial growth factor receptor 3(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50309549(3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50: 66nMAssay Description:Inhibition of VEGFR3 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50309549(3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50: 82nMAssay Description:Inhibition of VEGFR2 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50309549(3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50: 150nMAssay Description:Inhibition of VEGFR1 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50309549(3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50: 182nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
US Patent

TargetAngiopoietin-1 receptor(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50309549(3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of TIE2 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50309549(3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of PDGFRalpha after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50309549(3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50: 2.67E+3nMAssay Description:Inhibition of PDGFRbeta after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50309549(3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50: 3.47E+3nMAssay Description:Inhibition of KIT after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50309549(3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50: 8.48E+3nMAssay Description:Inhibition of EGFR after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50309549(3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50: 8.48E+3nMAssay Description:Inhibition of ERBB2 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50309549(3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Affinity DataIC50: 8.53E+3nMAssay Description:Inhibition of IGF1R after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed