BDBM50309960 (exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-trifluoromethyl, 4-fluorobenzyl)-(octahydro-cyclopenta[c]pyrrol-5-yl)-amide::CHEMBL596699

SMILES Cn1cnc(c1)C(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)[C@@H]1C[C@@H]2CNC[C@@H]2C1

InChI Key InChIKey=VAVBDQVWHLBYKB-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50309960   

LigandPNGBDBM50309960((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataKi:  1.70nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50309960((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataKi:  3.31E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50309960((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human glycine transporter 2-mediated glycine uptake expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50309960((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataIC50: 4.33E+3nMAssay Description:Inhibition of human ERG by patch clamp studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309960((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309960((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed