BDBM50309965 (exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-trifluoromethoxy-benzyl)-(2-(2-hydroxy, 2-methylpropyl)-octahydro-cyclopenta[c]pyrrol-5-yl)-amide::CHEMBL605744

SMILES Cn1cnc(c1)C(=O)N(Cc1cccc(OC(F)(F)F)c1)[C@H]1C[C@H]2CN(CC(C)(C)O)C[C@H]2C1

InChI Key InChIKey=ARKYOPPYXOUDRK-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50309965   

LigandPNGBDBM50309965((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataKi:  5.70nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309965((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50309965((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataKi:  3.81E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50309965((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataIC50: 8.87E+3nMAssay Description:Inhibition of human glycine transporter 2-mediated glycine uptake expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309965((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed