BDBM50310469 2-(4-amino-1,2,5-oxadiazol-3-yl)-1-cyclobutyl-1H-benzo[d]imidazol-5-ol::CHEMBL1079032

SMILES Nc1nonc1-c1nc2cc(O)ccc2n1C1CCC1

InChI Key InChIKey=WLLKDVLVMGFFIJ-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50310469   

TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310469BDBM50310469(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-cyclobutyl-1H-b...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of GSK3-beta assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310469BDBM50310469(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-cyclobutyl-1H-b...)
Affinity DataKi:  2.20E+3nMAssay Description:Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310469BDBM50310469(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-cyclobutyl-1H-b...)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed