BDBM50310478 2-(4-amino-1,2,5-oxadiazol-3-yl)-1-isobutyl-1H-imidazole-4-carbonitrile::CHEMBL1082061

SMILES CC(C)Cn1cc(nc1-c1nonc1N)C#N

InChI Key InChIKey=RIQVGHLUYJLYMD-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50310478   

TargetRibosomal protein S6 kinase beta-1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310478BDBM50310478(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-isobutyl-1H-imi...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310478BDBM50310478(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-isobutyl-1H-imi...)
Affinity DataKi: >3.30E+3nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310478BDBM50310478(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-isobutyl-1H-imi...)
Affinity DataKi: >3.30E+3nMAssay Description:Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310478BDBM50310478(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-isobutyl-1H-imi...)
Affinity DataKi: >3.30E+3nMAssay Description:Inhibition of GSK3-beta assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed