BDBM50311018 CHEMBL1078363::N-(cyanomethyl)-2-methyl-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide::US12570614, Compound 11

SMILES Cc1cc(ccc1C(=O)NCC#N)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1

InChI Key InChIKey=HFNYDUGXJCRIRE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50311018   

TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311018BDBM50311018(N-(cyanomethyl)-2-methyl-4-(2-(4-morpholinophenyla...)
Affinity DataIC50: 65nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311018BDBM50311018(N-(cyanomethyl)-2-methyl-4-(2-(4-morpholinophenyla...)
Affinity DataIC50: 1.00E+3nMAssay Description:The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Cytopia Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311018BDBM50311018(N-(cyanomethyl)-2-methyl-4-(2-(4-morpholinophenyla...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of GST-tagged JAK3 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed