BDBM50311030 CHEMBL1077842::N-Cyanomethyl-4-{2-[4-(1,1-dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-phenylamino]-pyrimidin-4-yl}-benzamide::US12570614, Compound 90

SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(CN3CCS(=O)(=O)CC3)cc2)n1

InChI Key InChIKey=QYRJYUJVVWXZQA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50311030   

TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311030BDBM50311030(N-Cyanomethyl-4-{2-[4-(1,1-dioxo-1lambda*6*-thiomo...)
Affinity DataIC50: 52nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cytopia Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311030BDBM50311030(N-Cyanomethyl-4-{2-[4-(1,1-dioxo-1lambda*6*-thiomo...)
Affinity DataIC50: 364nMAssay Description:Inhibition of GST-tagged JAK3 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311030BDBM50311030(N-Cyanomethyl-4-{2-[4-(1,1-dioxo-1lambda*6*-thiomo...)
Affinity DataIC50: 1.00E+3nMAssay Description:The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Cytopia Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311030BDBM50311030(N-Cyanomethyl-4-{2-[4-(1,1-dioxo-1lambda*6*-thiomo...)
Affinity DataIC50: 5.00E+3nMAssay Description:The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2026
Entry Details
US Patent