BDBM50311032 CHEMBL1078934::N-(cyanomethyl)-4-(2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)benzamide::US12570614, Compound 44

SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2ccc(cc2)C(=O)NCC#N)cc1

InChI Key InChIKey=JWNVJLOTJWLIAA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50311032   

TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311032BDBM50311032(N-(cyanomethyl)-4-(2-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 41nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cytopia Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311032BDBM50311032(N-(cyanomethyl)-4-(2-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 192nMAssay Description:Inhibition of GST-tagged JAK3 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311032BDBM50311032(N-(cyanomethyl)-4-(2-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+3nMAssay Description:The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Cytopia Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311032BDBM50311032(N-(cyanomethyl)-4-(2-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 5.00E+3nMAssay Description:The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2026
Entry Details
US Patent