BDBM50311413 CHEMBL1078595::N-(3-((1H-pyrazol-3-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-6-morpholinopyridine-3-sulfonamide

SMILES O=S(=O)(Nc1ccc2CCN(Cc3ccn[nH]3)CCc2c1)c1ccc(nc1)N1CCOCC1

InChI Key InChIKey=ZRAVHLYAOHIXOD-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50311413   

TargetMotilin receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311413(N-(3-((1H-pyrazol-3-yl)methyl)-2,3,4,5-tetrahydro-...)
Affinity DataEC50:  6.31nMAssay Description:Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311413(N-(3-((1H-pyrazol-3-yl)methyl)-2,3,4,5-tetrahydro-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311413(N-(3-((1H-pyrazol-3-yl)methyl)-2,3,4,5-tetrahydro-...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human ghrelin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311413(N-(3-((1H-pyrazol-3-yl)methyl)-2,3,4,5-tetrahydro-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human recombinant CYP3A4 using 7-{3-(4-phenylpiperazin-1-ylmethyl)benzyl}resorufin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311413(N-(3-((1H-pyrazol-3-yl)methyl)-2,3,4,5-tetrahydro-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human recombinant CYP3A4 using diethoxyfluorescein as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311413(N-(3-((1H-pyrazol-3-yl)methyl)-2,3,4,5-tetrahydro-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human recombinant CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311413(N-(3-((1H-pyrazol-3-yl)methyl)-2,3,4,5-tetrahydro-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311413(N-(3-((1H-pyrazol-3-yl)methyl)-2,3,4,5-tetrahydro-...)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed