BDBM50311726 CHEMBL1081196::N-ethyl-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)benzo[d]thiazole-2-carboxamide

SMILES CCN(Cc1cccc(OC)c1)C(=O)c1nc2ccc(cc2s1)-c1cn[nH]c1

InChI Key InChIKey=QUMAYKINOQNINW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50311726   

TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311726(N-ethyl-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)ben...)
Affinity DataIC50: 26nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311726(N-ethyl-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)ben...)
Affinity DataIC50: 180nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311726(N-ethyl-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)ben...)
Affinity DataIC50: 455nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311726(N-ethyl-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)ben...)
Affinity DataIC50: 7.86E+3nMAssay Description:Inhibition of MRCKalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311726(N-ethyl-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)ben...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed