BDBM50312224 CHEMBL1079580::N-Benzyloxycarbonylamino-glycine-2R-pyrrolidine-2-carbonitrile

SMILES O=C(NCC(=O)N1CCC[C@@H]1C#N)OCc1ccccc1

InChI Key InChIKey=GMYAYIPUIKOHDZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50312224   

TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312224(N-Benzyloxycarbonylamino-glycine-2R-pyrrolidine-2-...)
Affinity DataIC50: 430nMAssay Description:Inhibition of prolyl oligopeptidase in human LNZ308 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312224(N-Benzyloxycarbonylamino-glycine-2R-pyrrolidine-2-...)
Affinity DataIC50: 430nMAssay Description:Inhibition of prolyl oligopeptidase in human LN229 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312224(N-Benzyloxycarbonylamino-glycine-2R-pyrrolidine-2-...)
Affinity DataIC50: 690nMAssay Description:Inhibition of prolyl oligopeptidase in human HCEC cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312224(N-Benzyloxycarbonylamino-glycine-2R-pyrrolidine-2-...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human HCEC cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312224(N-Benzyloxycarbonylamino-glycine-2R-pyrrolidine-2-...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LN229 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312224(N-Benzyloxycarbonylamino-glycine-2R-pyrrolidine-2-...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LNZ308 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed