BDBM50312630 CHEMBL1094710::Octanedioic Acid-[3-(4-Cyclohexyl-[1,2,3]triazol-1-yl)phenyl]-amide-Hydroxyamide

SMILES ONC(=O)CCCCCCC(=O)Nc1cccc(c1)-n1cc(nn1)C1CCCCC1

InChI Key InChIKey=SGTCWQOXXQUYHN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50312630   

TargetHistone deacetylase 6(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50312630(Octanedioic Acid-[3-(4-Cyclohexyl-[1,2,3]triazol-1...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of HDAC6 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50312630(Octanedioic Acid-[3-(4-Cyclohexyl-[1,2,3]triazol-1...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of HDAC3 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50312630(Octanedioic Acid-[3-(4-Cyclohexyl-[1,2,3]triazol-1...)
Affinity DataIC50: 12.1nMAssay Description:Inhibition of HDAC1 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50312630(Octanedioic Acid-[3-(4-Cyclohexyl-[1,2,3]triazol-1...)
Affinity DataIC50: 16.6nMAssay Description:Inhibition of HDAC10 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50312630(Octanedioic Acid-[3-(4-Cyclohexyl-[1,2,3]triazol-1...)
Affinity DataIC50: 48.2nMAssay Description:Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50312630(Octanedioic Acid-[3-(4-Cyclohexyl-[1,2,3]triazol-1...)
Affinity DataIC50: 2.75E+3nMAssay Description:Inhibition of HDAC8 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed