BDBM50313051 (Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazono)-1H-pyrazol-5(4H)-one::CHEMBL1076721

SMILES COc1ccc(cc1)-c1[nH][nH]c(=O)c1N=Nc1cccnc1

InChI Key InChIKey=KRHWSBXYWJHICK-UHFFFAOYSA-N

Data  13 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50313051   

TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50313051((Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazo...)
Affinity DataKi:  2nMAssay Description:Inhibition of GSK3-beta assessed as NADH level after 10 mins by pyruvate kinase/lactate dehydrogenase coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50313051((Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazo...)
Affinity DataKi:  62nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50313051((Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazo...)
Affinity DataKi:  130nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50313051((Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazo...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50313051((Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazo...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50313051((Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazo...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50313051((Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazo...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50313051((Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazo...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50313051((Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazo...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50313051((Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazo...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50313051((Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazo...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50313051((Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazo...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50313051((Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazo...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed