BDBM50313220 2-{[(3',4'-Dichloro-biphenyl-4-ylcarbamoyl)-methyl]-sulfamoyl}-benzoic acid::CHEMBL1080553

SMILES OC(=O)c1ccccc1S(=O)(=O)NCC(=O)Nc1ccc(cc1)-c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=DETCJXKUURQYRY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50313220   

TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313220BDBM50313220(2-{[(3',4'-Dichloro-biphenyl-4-ylcarbamoyl)-methyl...)
Affinity DataIC50: 5.76E+3nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313220BDBM50313220(2-{[(3',4'-Dichloro-biphenyl-4-ylcarbamoyl)-methyl...)
Affinity DataIC50: 3.76E+4nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313220BDBM50313220(2-{[(3',4'-Dichloro-biphenyl-4-ylcarbamoyl)-methyl...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human COX2 in IL-1beta treated human FF cells assessed as blockade of SnCl2-mediated PGH2 to PGF2alpha conversion after 50 mins by ELIS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed