BDBM50314344 4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)methyl)-1-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzamide::CHEMBL1092754

SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccc(cc1)C(=O)NCCO

InChI Key InChIKey=YDELNSXADYPQGS-BKUYFWCQSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50314344   

TargetProtein kinase C alpha type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  50nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of GCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  39nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  50nMAssay Description:Inhibition of IKKalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  50nMAssay Description:Inhibition of P38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  28nMAssay Description:Inhibition of LYN AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  50nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  36nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of ABL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  50nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  46nMAssay Description:Inhibition of RSK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  11nMAssay Description:Inhibition of GSK3alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  50nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of cMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  2.71E+4nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50:  2.22E+4nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed