BDBM50314600 2-amino-4-(3',5'-difluorobiphenyl-3-yl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL1091463

SMILES CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cc(F)cc(F)c1

InChI Key InChIKey=AYXHXAPMJNZSFH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50314600   

TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314600(2-amino-4-(3',5'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50: 60nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314600(2-amino-4-(3',5'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314600(2-amino-4-(3',5'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50: 60nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314600(2-amino-4-(3',5'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50: 3.41E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed