BDBM50318078 8-[(2-Acetylphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1099104

SMILES CC(=O)c1ccccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O

InChI Key InChIKey=NUQUWKXNHFMEAJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50318078   

TargetSerine/threonine-protein kinase PLK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318078BDBM50318078(8-[(2-Acetylphenyl)amino]-1-methyl-4,5-dihydro-1H-...)
Affinity DataIC50: 103nMAssay Description:Inhibition of Plk3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318078BDBM50318078(8-[(2-Acetylphenyl)amino]-1-methyl-4,5-dihydro-1H-...)
Affinity DataIC50: 261nMAssay Description:Inhibition of Plk2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318078BDBM50318078(8-[(2-Acetylphenyl)amino]-1-methyl-4,5-dihydro-1H-...)
Affinity DataIC50: 346nMAssay Description:Inhibition of GST-tagged PLK1 expressed in H5 insect cells assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318078BDBM50318078(8-[(2-Acetylphenyl)amino]-1-methyl-4,5-dihydro-1H-...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of CDK2/Cyclin A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318078BDBM50318078(8-[(2-Acetylphenyl)amino]-1-methyl-4,5-dihydro-1H-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed