BDBM50318464 CHEMBL1086339::N-(4-sec-butylphenyl)-2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetamide

SMILES CCC(C)c1ccc(NC(=O)Cn2cnc3n(C)c(=O)n(C)c(=O)c23)cc1

InChI Key InChIKey=ZUTUWJYMCADJHD-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50318464   

LigandPNGBDBM50318464(N-(4-sec-butylphenyl)-2-(1,3-dimethyl-2,6-dioxo-2,...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase in intracellular calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50318464(N-(4-sec-butylphenyl)-2-(1,3-dimethyl-2,6-dioxo-2,...)
Affinity DataIC50: 1.43E+4nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318464(N-(4-sec-butylphenyl)-2-(1,3-dimethyl-2,6-dioxo-2,...)
Affinity DataIC50: 1.87E+4nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of 4-hydroxy-2-nonenal-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318464(N-(4-sec-butylphenyl)-2-(1,3-dimethyl-2,6-dioxo-2,...)
Affinity DataEC50:  2.50E+6nMAssay Description:Activation of mouse TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed