BDBM50319634 CHEMBL1084892::N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(methylamino)-2-phenylacetamide

SMILES CNC(C(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl)c1ccccc1

InChI Key InChIKey=SAGGCAPQVJYEGE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50319634   

TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319634(N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(...)
Affinity DataIC50: 12nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319634(N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(...)
Affinity DataIC50: 12nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319634(N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(...)
Affinity DataIC50: 14nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319634(N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(...)
Affinity DataIC50: 110nMAssay Description:Inhibition of Prkcl2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCell division control protein 42 homolog(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319634(N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CDc42More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetMyotonin-protein kinase(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319634(N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of DMPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319634(N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of PrkceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed