BDBM50319843 (S)-4-(1-(5-chloro-1-(3-chlorobenzyl)-1H-indole-7-carboxamido)ethyl)benzoic acid::CHEMBL1085040

SMILES C[C@H](NC(=O)c1cc(Cl)cc2ccn(Cc3cccc(Cl)c3)c12)c1ccc(cc1)C(O)=O

InChI Key InChIKey=LFJXCZVMRYLIQY-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50319843   

TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50319843((S)-4-(1-(5-chloro-1-(3-chlorobenzyl)-1H-indole-7-...)
Affinity DataKi:  0.810nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50319843((S)-4-(1-(5-chloro-1-(3-chlorobenzyl)-1H-indole-7-...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50319843((S)-4-(1-(5-chloro-1-(3-chlorobenzyl)-1H-indole-7-...)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]PGD2 from human Prostanoid DP1 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed