BDBM50324057 2-Amino-6-(pyrrolidin-1'-yl)-4-phenylpyridine-3,5-dicarbonitrile::CHEMBL1215029

SMILES Nc1nc(N2CCCC2)c(C#N)c(-c2ccccc2)c1C#N

InChI Key InChIKey=DQDILNDNGZRYFK-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50324057   

TargetAdenosine receptor A2a(Human)
University of Geneva

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324057BDBM50324057(2-Amino-6-(pyrrolidin-1'-yl)-4-phenylpyridine-3,5-...)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to A2A receptor (unknown origin) assessed as dissociation constant at 1000 nM by Grating-coupled interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Geneva

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324057BDBM50324057(2-Amino-6-(pyrrolidin-1'-yl)-4-phenylpyridine-3,5-...)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to A2A receptor (unknown origin) assessed as dissociation constant at 100 nM by Grating-coupled interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324057BDBM50324057(2-Amino-6-(pyrrolidin-1'-yl)-4-phenylpyridine-3,5-...)
Affinity DataIC50: 420nMAssay Description:Negative allosteric modulation of A2AR (unknown origin) expressed in CHO cells in presence of adenosine by CamBio assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCarboxylic ester hydrolase(Horse)
Laboratorio De Radicales Libres Y QuíMica Computacional (Iqog, Csic)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324057BDBM50324057(2-Amino-6-(pyrrolidin-1'-yl)-4-phenylpyridine-3,5-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of equine serum BuChE after 10 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Laboratorio De Radicales Libres Y QuíMica Computacional (Iqog, Csic)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324057BDBM50324057(2-Amino-6-(pyrrolidin-1'-yl)-4-phenylpyridine-3,5-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Electrophorus electricus AChE after 10 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed