BDBM50325822 CHEMBL1224527::trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[h]isoquinoline-7,8-diol

SMILES Oc1ccc2[C@@H]3CNCC[C@H]3[C@@H](Cc2c1O)c1ccccc1

InChI Key InChIKey=FKYWSGYMKJUZEP-UHFFFAOYSA-N

Data  15 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50325822   

TargetD(1A) dopamine receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataEC50:  0.640nMAssay Description:Agonist activity at human D1 receptor assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  210nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  230nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D2long receptor expressed in HEK293 cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  1.10E+3nMAssay Description:Binding affinity to adrenergic Alpha-2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  2.80E+3nMAssay Description:Binding affinity to dopamine D5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  3.50E+3nMAssay Description:Binding affinity to adrenergic alpha2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  6.40E+3nMAssay Description:Binding affinity to adrenergic alpha2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  1.80E+4nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  1.30E+5nMAssay Description:Binding affinity to dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  2.20E+5nMAssay Description:Binding affinity to 5HT7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  3.40E+5nMAssay Description:Binding affinity to adrenergic alpha1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  7.50E+5nMAssay Description:Binding affinity to dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  8.20E+5nMAssay Description:Binding affinity to adrenergic kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  8.70E+5nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50325822(trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobe...)
Affinity DataKi:  2.65E+6nMAssay Description:Binding affinity to dopamine D4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed