BDBM50328414 CHEMBL1258603::E/Z-(S)-5-fluoro-3-((4-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)ethoxy)-3-methylazulen-1-yl)methylene)indolin-2-one

SMILES Cc1cc(C=C2C(=O)Nc3ccc(F)cc23)c2ccccc(OCCN3CCC[C@H]3CO)c12

InChI Key InChIKey=ZAXCRUCBIGQULY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50328414   

TargetPlatelet-derived growth factor receptor beta(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328414(E/Z-(S)-5-fluoro-3-((4-(2-(2-(hydroxymethyl)pyrrol...)
Affinity DataIC50: 28nMAssay Description:Inhibition of PDGFRbeta autophosphorylation by cell based Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328414(E/Z-(S)-5-fluoro-3-((4-(2-(2-(hydroxymethyl)pyrrol...)
Affinity DataIC50: 44nMAssay Description:Inhibition of c-Kit autophosphorylation in human Kasumi-1 cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328414(E/Z-(S)-5-fluoro-3-((4-(2-(2-(hydroxymethyl)pyrrol...)
Affinity DataIC50: 70nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328414(E/Z-(S)-5-fluoro-3-((4-(2-(2-(hydroxymethyl)pyrrol...)
Affinity DataIC50: 98nMAssay Description:Inhibition of FLT3 by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328414(E/Z-(S)-5-fluoro-3-((4-(2-(2-(hydroxymethyl)pyrrol...)
Affinity DataIC50: 186nMAssay Description:Inhibition of KDR autophosphorylation in HUVEC by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed