BDBM50329217 CHEMBL1271106::N-(2-Methylbenzyl)-6-(4-trifluoromethoxyphenyl)-pyrazine-2-carboxamide::N-(3,5-dimethylphenyl)-6-(4-(trifluoromethoxy)phenyl)pyrazine-2-carboxamide

SMILES Cc1cc(C)cc(NC(=O)c2cncc(n2)-c2ccc(OC(F)(F)F)cc2)c1

InChI Key InChIKey=ZAXMOONEIUJTOM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50329217   

TargetSodium channel protein type 10 subunit alpha(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329217(CHEMBL1271106 | N-(2-Methylbenzyl)-6-(4-trifluorom...)
Affinity DataIC50:  34nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329217(CHEMBL1271106 | N-(2-Methylbenzyl)-6-(4-trifluorom...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329217(CHEMBL1271106 | N-(2-Methylbenzyl)-6-(4-trifluorom...)
Affinity DataIC50:  58nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329217(CHEMBL1271106 | N-(2-Methylbenzyl)-6-(4-trifluorom...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329217(CHEMBL1271106 | N-(2-Methylbenzyl)-6-(4-trifluorom...)
Affinity DataIC50:  34nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329217(CHEMBL1271106 | N-(2-Methylbenzyl)-6-(4-trifluorom...)
Affinity DataIC50:  57nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed