BDBM50330248 6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimethyl-2,2'-binaphthyl-1,1',4,4'-tetraone::CHEMBL1272224

SMILES CC(C)C=c1c(O)c(O)cc2c(O)c(-c3c(O)c4cc(O)c(O)c(=CC(C)C)c4c(O)c3=C)c(=C)c(O)c12

InChI Key InChIKey=IYWGIHNKFVTBBS-UHFFFAOYSA-N

Data  4 KI  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50330248   

TargetApoptosis regulator Bcl-2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330248(6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimeth...)
Affinity DataKi:  170nMAssay Description:Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330248(6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimeth...)
Affinity DataIC50: 250nMAssay Description:Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330248(6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimeth...)
Affinity DataKi:  310nMAssay Description:Displacement of F-BakBH3 from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330248(6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimeth...)
Affinity DataKi:  370nMAssay Description:Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330248(6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimeth...)
Affinity DataIC50: 470nMAssay Description:Displacement of F-BakBH3 from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330248(6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimeth...)
Affinity DataIC50: 550nMAssay Description:Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330248(6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimeth...)
Affinity DataKi:  930nMAssay Description:Displacement of F-BakBH3 from Bfl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330248(6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimeth...)
Affinity DataIC50: 1.41E+3nMAssay Description:Displacement of F-BakBH3 from Bfl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330248(6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimeth...)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity Bcl-xL by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed