BDBM50330255 6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(3-phenylpropyl)-2,2'-binaphthyl-1,1',4,4'-tetraone::CHEMBL1269077

SMILES Oc1cc2c(O)c(-c3c(O)c4cc(O)c(O)c(=CCCc5ccccc5)c4c(O)c3=C)c(=C)c(O)c2c(=CCCc2ccccc2)c1O

InChI Key InChIKey=BXOYLPBDGPSTAE-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50330255   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330255(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(3-ph...)
Affinity DataKi:  450nMAssay Description:Displacement of F-BakBH3 from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330255(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(3-ph...)
Affinity DataIC50: 670nMAssay Description:Displacement of F-BakBH3 from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330255(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(3-ph...)
Affinity DataKi:  960nMAssay Description:Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330255(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(3-ph...)
Affinity DataIC50: 1.44E+3nMAssay Description:Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330255(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(3-ph...)
Affinity DataKi:  1.45E+3nMAssay Description:Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330255(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(3-ph...)
Affinity DataIC50: 2.17E+3nMAssay Description:Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330255(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(3-ph...)
Affinity DataKi:  3.53E+3nMAssay Description:Displacement of F-BakBH3 from Bfl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330255(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(3-ph...)
Affinity DataIC50: 5.27E+3nMAssay Description:Displacement of F-BakBH3 from Bfl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed