BDBM50331556 2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-dioxobutan-2-yl)-4-(pyridin-2-ylmethoxy)-3-(trifluoromethyl)benzamide::CHEMBL1289644

SMILES CC(NC(=O)c1ccc(OCc2ccccn2)c(c1Cl)C(F)(F)F)C(=O)C(=O)Nc1ccn(C)n1

InChI Key InChIKey=AEACXIXTPAQTGN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50331556   

TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331556(2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331556(2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 12.9nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331556(2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 36.3nMAssay Description:Inhibition of human cathepsin V by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331556(2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 479nMAssay Description:Inhibition of human cathepsin L by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331556(2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of human cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed