BDBM50331557 2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-dioxopentan-3-yl)-4-(pyridin-2-ylmethoxy)-3-(trifluoromethyl)benzamide::CHEMBL1289645

SMILES CCC(NC(=O)c1ccc(OCc2ccccn2)c(c1Cl)C(F)(F)F)C(=O)C(=O)Nc1ccn(C)n1

InChI Key InChIKey=ABGBBQLBNIVODC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50331557   

TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331557(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331557(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 16.6nMAssay Description:Inhibition of human cathepsin V by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331557(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 20.9nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331557(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 78nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as Lip10 accumulation by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331557(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 141nMAssay Description:Inhibition of human cathepsin L by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331557(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 3.24E+3nMAssay Description:Inhibition of human cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed