BDBM50332233 (R)-2-((6-(3-amino-3-methylpiperidin-1-yl)-1-ethyl-3-methyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,2-d]pyrimidin-5(2H)-yl)methyl)-4-fluorobenzonitrile hydrochloride::CHEMBL1288288

SMILES CCn1c2cc(N3CCC[C@@](C)(N)C3)n(Cc3cc(F)ccc3C#N)c2c(=O)n(C)c1=O

InChI Key InChIKey=LGHBEIDFUUJBSV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50332233   

TargetDipeptidyl peptidase 4(Human)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50332233((R)-2-((6-(3-amino-3-methylpiperidin-1-yl)-1-ethyl...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human plasma DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50332233((R)-2-((6-(3-amino-3-methylpiperidin-1-yl)-1-ethyl...)
Affinity DataIC50: 400nMAssay Description:Inhibition of CYP2D6 in human liver microsomes after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50332233((R)-2-((6-(3-amino-3-methylpiperidin-1-yl)-1-ethyl...)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50332233((R)-2-((6-(3-amino-3-methylpiperidin-1-yl)-1-ethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50332233((R)-2-((6-(3-amino-3-methylpiperidin-1-yl)-1-ethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50332233((R)-2-((6-(3-amino-3-methylpiperidin-1-yl)-1-ethyl...)
Affinity DataIC50: 2.68E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed