BDBM50332633 CHEMBL1630806::N-(4-Methylphenyl)-7-oxo-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide

SMILES Cc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1

InChI Key InChIKey=NPHYMBSICKDZQU-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50332633   

TargetMetabotropic glutamate receptor 2(Human)
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332633(N-(4-Methylphenyl)-7-oxo-7,7a-dihydrocyclopropa[b]...)
Affinity DataKi:  600nMAssay Description:Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332633(N-(4-Methylphenyl)-7-oxo-7,7a-dihydrocyclopropa[b]...)
Affinity DataIC50: 1.50E+3nMAssay Description:Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332633(N-(4-Methylphenyl)-7-oxo-7,7a-dihydrocyclopropa[b]...)
Affinity DataEC50:  8.90E+3nMAssay Description:Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed