BDBM50333027 3-(Pyridin-4-ylethynyl)-1H-indazole::CHEMBL1631892

SMILES c1ccc2c(n[nH]c2c1)C#Cc1ccncc1

InChI Key InChIKey=SHPLHKPOBQVQPG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50333027   

LigandPNGBDBM50333027(3-(Pyridin-4-ylethynyl)-1H-indazole | CHEMBL163189...)
Affinity DataIC50: 360nMAssay Description:Inhibition of PI3Kalpha by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50333027(3-(Pyridin-4-ylethynyl)-1H-indazole | CHEMBL163189...)
Affinity DataIC50: 3.87E+3nMAssay Description:Inhibition of PDK1 by Z'-LYTE kinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50333027(3-(Pyridin-4-ylethynyl)-1H-indazole | CHEMBL163189...)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of mTOR by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50333027(3-(Pyridin-4-ylethynyl)-1H-indazole | CHEMBL163189...)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of mTORC1 expressed in HEK293 cells assessed as PRAS40 Ser183 phosphorylation level by LanthaScreen cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50333027(3-(Pyridin-4-ylethynyl)-1H-indazole | CHEMBL163189...)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50333027(3-(Pyridin-4-ylethynyl)-1H-indazole | CHEMBL163189...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed