BDBM50333219 6-(6-methoxypyridin-3-yl)benzo[d]thiazol-2-amine::CHEMBL1645105

SMILES COc1ccc(cn1)-c1ccc2nc(N)sc2c1

InChI Key InChIKey=CBBGVZCNBLEQID-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50333219   

LigandPNGBDBM50333219(6-(6-methoxypyridin-3-yl)benzo[d]thiazol-2-amine |...)
Affinity DataIC50:  398nMAssay Description:Inhibition of PI3Kgamma (unknown origin) pre-incubated for 20 mins before phosphatidylinositol 4, 5-bisphosphate substrate addition by kinase-glo plu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50333219(6-(6-methoxypyridin-3-yl)benzo[d]thiazol-2-amine |...)
Affinity DataIC50:  794nMAssay Description:Inhibition of PI3Kdelta (unknown origin) pre-incubated for 20 mins before phosphatidylinositol 4, 5-bisphosphate substrate addition by kinase-glo plu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50333219(6-(6-methoxypyridin-3-yl)benzo[d]thiazol-2-amine |...)
Affinity DataIC50:  2.51E+4nMAssay Description:Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase AssayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50333219(6-(6-methoxypyridin-3-yl)benzo[d]thiazol-2-amine |...)
Affinity DataIC50:  794nMAssay Description:Inhibition of PI3Kalpha (unknown origin) pre-incubated for 20 mins before phosphatidylinositol 4, 5-bisphosphate substrate addition by kinase-glo plu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50333219(6-(6-methoxypyridin-3-yl)benzo[d]thiazol-2-amine |...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human PI3K p110beta catalytic subunit by AlphaScreen competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50333219(6-(6-methoxypyridin-3-yl)benzo[d]thiazol-2-amine |...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50333219(6-(6-methoxypyridin-3-yl)benzo[d]thiazol-2-amine |...)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) pre-incubated for 20 mins before phosphatidylinositol 4, 5-bisphosphate substrate addition by kinase-glo plus...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50333219(6-(6-methoxypyridin-3-yl)benzo[d]thiazol-2-amine |...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human p110alpha PI3K fragment by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50333219(6-(6-methoxypyridin-3-yl)benzo[d]thiazol-2-amine |...)
Affinity DataIC50:  631nMAssay Description:Inhibition of N-terminal FLAG-tagged human full length recombinant PI4K3alpha using D-myo-phosphatidylinositol substrate and ATP incubated for 45 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed