BDBM50333450 (R)-3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)pyrrolidine::CHEMBL1645617

SMILES Fc1cccc(Oc2c(F)cccc2Cl)c1O[C@@H]1CCNC1

InChI Key InChIKey=PDVOMSJUMYNNBT-UHFFFAOYSA-N

Data  4 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50333450   

Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333450((R)-3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenox...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333450((R)-3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenox...)
Affinity DataEC50:  77nMAssay Description:Agonist activity at 5HT1A receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333450((R)-3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenox...)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333450((R)-3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenox...)
Affinity DataKi: >4.53E+3nMAssay Description:Displacement of [3H]citalopram from human SERT by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333450((R)-3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenox...)
Affinity DataKi: >5.87E+3nMAssay Description:Displacement of [3H]WIN-35,428 from human DAT by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed