BDBM50333972 CHEMBL1644605::exo-2-((1R,5S)-8-azabicyclo[3.2.1]octan-3-yloxy)-6-phenylisonicotinonitrile

SMILES N#Cc1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3)nc(c1)-c1ccccc1

InChI Key InChIKey=NRKLSKYRBUUDLU-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50333972   

LigandPNGBDBM50333972(exo-2-((1R,5S)-8-azabicyclo[3.2.1]octan-3-yloxy)-6...)
Affinity DataIC50: 90nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50333972(exo-2-((1R,5S)-8-azabicyclo[3.2.1]octan-3-yloxy)-6...)
Affinity DataKi:  119nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50333972(exo-2-((1R,5S)-8-azabicyclo[3.2.1]octan-3-yloxy)-6...)
Affinity DataIC50: 208nMAssay Description:Inhibition of [3H]serotonin reuptake at SERT expressed in HEK293 cells scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50333972(exo-2-((1R,5S)-8-azabicyclo[3.2.1]octan-3-yloxy)-6...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of [3H]dopamine reuptake at DAT expressed in HEK293 cells scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed