BDBM503355 6-amino-2-[3-(aminomethyl)-3- methylazetidin-1-yl]-5-(2,3- dichlorophenyl)pyrimidine-4- carboxamide::US11033547, Compound 55::US11696916, Compound 55

SMILES CC1(CN)CN(C1)c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O

InChI Key InChIKey=NGIUTQIZUNYKTH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503355   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 503355BDBM503355(6-amino-2-[3-(aminomethyl)-3- methylazetidin-1-yl]...)
Affinity DataIC50: 1.70E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 503355BDBM503355(6-amino-2-[3-(aminomethyl)-3- methylazetidin-1-yl]...)
Affinity DataIC50: 1.70E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent